Space-saving, efficient and safe: Smart WFI dispensing systems
Compact POU Dispensing Systems with innovative flowmeter - Cooperation with Exergy
Leading pharmaceutical companies around the world rely on Exergy for their Point-of-Use (POU) Dispensing Systems. With its unique turn-key PureX solutions, the company sets the benchmark in the sterile, cost- and space-saving dispensing of ultrapure water and water for injection (WFI) from hot WFI loops. Exergy achieves this not least thanks to the compact components from Bürkert.
24/7 safe and sterile operation
PureX POU Dispensing Systems, a collaboration between Exergy, LLC and Hydropure Pvt Ltd., are equipped with Exergy’s compact, high-performance shell and tube heat exchangers to deliver temperature-controlled WFI/PW on demand in under 30 seconds. The PureX systems can be configured to dispense anywhere from 100–18 000 LPH of cool WFI at process temperatures down to as low as 10–15 °C. Over 1 000 PureX Dispensing Systems have been installed globally with projects at most of the major pharmaceutical companies providing reliable precision cooling for a variety of process demands. At the core of the cooling control process are Bürkert actuated control valve type 2301 with integrated digital positioner type 8694 which have been integral on PureX systems since they were first introduced. PureX systems are designed and manufactured to the rigorous quality requirements and hygienic standards of the pharmaceutical industry. When installed and not in use (i.e. standby), a continuous flow of hot WFI circulates through the system to provide continuous sanitization of all product contact components. The Exergy zeromaintenance Heat Exchangers are uniquely designed for the PureX applications and selected to ensure turbulent flow is maintained through all system components.
Exergy POU Dispensing Systems utilise a sub-loop with a continuous flow of hot WFI, which r eliably prevents microbial
growth and cross-contamination. PureX systems automatically provide cool WFI on demand at individual use points
while keeping the balance of the main loop hot, providing maximum flexibility for operations demands.
Compact and cost-saving monitoring
Introduction of the Bürkert type 8098 FLOWave flow sensor into the PureX design allows for convenient setting of the standby flow rate and continuous monitoring of the system status. “We first integrated FLOWave directly into our systems around five years ago. One of our large international pharmaceutical customers wanted to simplify the process of commissioning projects where high numbers of PureX systems were installed. Having a FLOWave in each cooler avoided the need to install clamp-on type meters and move them from system to system. This was especially beneficial when the coolers are installed in hard-toreach technical spaces,” says Thomas Bracco, Director of Program Management at Exergy. FLOWave determines the flow without any mediacontacting parts in the measuring pipe, thus ensuring aseptic operation. The flowmeter, which measures on the basis of surface acoustic waves and therefore without mechanically moving parts and vibrations, is significantly more compact and Total Cost of Ownership is very interesting compared to other flow measurement solutions. “Incorporating the compact FLOWave directly into the PureX systems also allows integration of additional features that increase operational efficiency and can reduce other CAPEX costs. With automated dispense valve positioners, it allows the Coolers to accurately modulate the dispense flow rate for different uses. With PureX Batching Software it enables automated precision dispensing of user-entered batch volumes,” adds Melissa Fryer, Director of Sales & Marketing at Exergy.
“Integrating the FLOWave into the PureX POU Dispensing System and having continuous availability of flow data reduces time and effort during commissioning activities, especially during initial start-up of the main WFI loop when conditions can be dynamic. Similarly, setting and verifying the flow rate after any type of maintenance is also simplified, avoiding the need to install external flowmeters.”
“Incorporating the compact FLOWave directly into the PureX systems allows integration of additional features that increase operational efficiency and can also reduce other CAPEX costs. With automated dispense valve positioners, it allows the Coolers to accurately modulate the dispense flow rate for different uses. With PureX Batching Software it enables automated precision dispensing of user-entered batch volumes.”
Sustainable and economical production
“Partnering with Exergy to incorporate custom PureX POU Dispensing Systems into your WFI distribution can result in significant year over year operating cost savings, reduced WFI waste, CAPEX savings, and all in compact turnkey cabinet solutions. A recent client who installed 18 POU Coolers serving over 45 individual use points in their new facility expects hundreds of thousands of dollars of savings per year in reduced WFI waste and energy savings. The smaller water consumption, waste and energy usage also provides added environmental benefits,” emphasises Melissa Fryer.
Peace of mind for the future
With the innovative concept of the PureX Dispensing Systems, Exergy enables its customers to operate their systems safely, cost-efficiently and sustainably today and in the future. The experts are always keen to consider the customer requirements of tomorrow.
PureX Pou Dispensing System
Did you know?
FLOWave uses Surface Acoustic Waves (SAW) technology to monitor the flow. With the innovative measuring principle, the flowmeter enables contactless and hygienic measurement, comes without any moving parts and determines several process parameters at once.
