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The smarter, the more efficient – Bürkert solutions for the Biotech industry 4.0

Single-use processes offer many advantages, especially in biotechnology, such as savings in cleaning biotechnical systems and improved process efficiency and the associated significantly reduced production times. Bürkert therefore supplies single-use solutions for more efficient and better production of biopharmaceutical drugs as well as digital interfaces for the Biotech industry 4.0.

 

Whether for upstream or downstream processes: Complex processes in the pharmaceutical industry, life science and drug production such as the production of monoclonal antibodies and vaccines require concepts that make the processes simpler and more efficient instead of making them more complex. This is exactly where Bürkert’s strength lies. With individual components, the integration of tailor-made modules or with turnkey system solutions, we achieve lean structures and automated processes by means of intelligent networking.

Always with the aim of shortening the time-to-market, saving resources and at the same time maintaining the high quality and hygiene standards in the Biotech industry. This is where our engineering competence, our expertise in fluidic control and measurement technology and our understanding of processes, applications and systems in biochemical engineering come into play.

Cell and Microorganism Cultures in Bioreactors and FermentersCell and Microorganism Cultures in Bioreactors and Fermenters

Unlike plant-based medicines, being prepared pharmaceutically from medicinal plants, and classic drugs produced chemically-synthetically, biopharmaceuticals’ production is more intricate: The complex molecules are biotechnologically produced using living organisms (bacteria, yeasts, as well as human, animal, and plant cells) – involving high technological effort. The heart of every biopharmaceutical process is the bioreactor or fermenter. High process safety, yield, and product quality are of utmost importance, and controlling the growth conditions is crucial. Find out how to optimise these in our white paper. 

Broad biotech portfolio

Whether single-use or multi-use – Our products and solutions are not only tailor-made, but also individually scalable according to your applications.

Support throughout the entire life cycle

For a sustainable, reliable use of our solutions, we advise and accompany you and bring our fluid know-how to your processes as a supplier and partner over the entire life cycle.

Individual project management

Our experts in the Bürkert Systemhaus teams will be happy to develop your systems and processes further in an agile manner in order to optimise processes continuously.

Efficient solutions for all Biotech applications

We would be happy to advise you on the specifications of your systems and the corresponding processes. Talk to us or use the contact form for a non-binding consultation.

Filtration
The requirement: Reduce dead volume and cross-contamination
The Bürkert solution: Multi-way valves with reduced contamination risk as well as modular construction set for reliable filter testing procedures, whereby there are fewer failed integrity tests and product loss is reduced.
Chromatography
The requirement: Precise media separation with minimal dead space with reduced space requirements
The Bürkert solution: This is where multi-way diaphragm valves and valve distributor blocks are used, also in single-use variants.
Pharma water
The requirement: Make WFI and pure steam quickly and easily available
The Bürkert solution: With the FLOWave flowmeter, we have developed a measuring device that makes process monitoring and diagnostics possible in real time – even media with low conductivity.
Fermentation
The requirement: Ensure consistent conditions and exact dosing of media.
The Bürkert solution: Valves, sensors, mass flow controllers for precise, automated and efficient control in a hygienic environment.
Filling and packaging
The requirement: Precise dosing in your filling line.
The Bürkert solution: The coordinated interaction of Bürkert flowmeters. Valves and software with batch functionality reduces product loss and boosts efficiency.

Measurably safe, measurably efficient

Movable parts

0

The measurement tube in the FLOWave flow meter is completely free of any parts that come into contact with the medium, apart from the tube itself.

Up to

35%

reduced total operating costs for bioreactors and fermenters by means of reduced maintenance thanks to Bürkert Mass Flow Controllers with long-term stable sensors.

Up to

45%

more compact control cabinets thanks to the smart installation concept and greater integrated range of functions of the Bürkert valve islands.

Bürkert Systemhaus – always open for the requirements of the Biotech industry 4.0

The development of digital control and measurement technology systems in biochemistry is complex and takes time. Use the know-how of our fluid control specialists to act more efficiently. We listen, analyse and develop future-oriented products and systems until they are ready for series production. You and your projects are always welcome in the Systemhaus – on site, by telephone or virtually.

Dosing, separating, controlling – our highlights for the Biotech industry

Type 8652

AirLINE – the valve island optimised for process automation

Type 8652
  • Safety-related shut-off of valves possible
  • Higher plant availability with PROFINET S2 (system redundancy)
  • Process reliability through pneumatic functions
  • Optimised for installation at the bottom of the control cabinet
  • EX-Versions: ATEX / IECEx Zone 2, cURus Haz. Loc. CL I, II, III Div 2
To product filterConfigure product

Type 8741

Mass flow controller (MFC)/mass flow meter (MFM) for gases

Type 8741
  • Nominal flow ranges from 0.010 l/min to 160 l/min
  • High accuracy and repeatability
  • Very fast response times
  • Simple device exchange due to configuration memory
  • Optional: USP Class VI, FDA, EC 1935 compliant
To product filter

 

From practice: Fluid solutions for biotech systems

Find out more about our products and solutions – or speak directly to our experts.

Diaphragm valves

Combining superior design, leading automation concepts and professional project handling

WFI circuit: Increasing security and saving operating costs with local control loops of valves and sensors

Water for injection (WFI) for the pharmaceutical industry requires special handling. Quality needs to be controlled and documented and flow velocities need to be measured and regulated so that purity and availability can be consistently guaranteed. The amounts of energy required for the production, distribution and storage of WFI result in significant operating costs. At the same time, environmental protection and sustainability are becoming increasingly important at many pharmaceutical companies. This makes the energy efficiency of a plant an important issue in the overall investment decision, a decision we are happy to help you with.

All bio pharmaceutical production under control

Like many sectors, the pharmaceutical industry is also undergoing digital change. Medicines have to be manufactured in ever faster time-to-market cycles, and pharmaceutical plants have to work more efficiently, more sustainably and more intelligently. Without jeopardising the highly sensitive process reliability.